Inhibition of influenza virus ribonucleic acid polymerase by ribavirin triphosphate.

نویسندگان

  • B Eriksson
  • E Helgstrand
  • N G Johansson
  • A Larsson
  • A Misiorny
  • J O Norén
  • L Philipson
  • K Stenberg
  • G Stening
  • S Stridh
  • B Oberg
چکیده

Ribavirin 5'-triphosphate (RTP), derived from the broad-spectrum antiviral compound ribavirin (Virazole), can selectively inhibit influenza virus ribonucleic acid polymerase in a cell-free assay. Ribavirin and its 5'-monophosphate have no effect on the polymerase. The inhibition is competitive with respect to adenosine 5'-triphosphate and guanosine 5'-triphosphate. RTP also inhibits ApG- and GpC-stimulated influenza virus ribonucleic acid polymerase. Since ribavirin is phosphorylated in the cell, the inhibition of influenza multiplication in the cell may also be caused by RTP.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 11 6  شماره 

صفحات  -

تاریخ انتشار 1977